1138

Material Data Sheet

Thapsigargin

Price: $99.00
Catalog #: 1138

Thapsigargin

Price: 
$99
Quantity: 
1 mg
Data Sheet: 

Product Information

MW: 
650.76
Purity: 
>97%
Solubility: 
Soluble to 100 mM in DMSO
Activity: 

Potent inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. Causes ER stress; can be used to induce autophagy in mammalian cells.

Storage: 
Desiccate at -20°C

Literature

References: 

 

Davidson and Varhol (1995) Kinetics of thapsigargin-Ca2+-ATPase (sarcoplasmic reticulum) interaction reveals a two-step binding mechanism and picomolar inhibition. J.Biol.Chem. 270 11731. PMID: 7744817.

Treiman et al (1998) A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases. TiPS 19 131. PMID: 9612087.

Yu et al (1998) Specific substitutions at amino acid 256 of the sarcoplasmic/endoplasmic reticulum Ca2+ transport ATPase mediate resistance to thapsigargin in thapsigargin-resistant hamster cells. J.Biol.Chem. 273 3542. PMID:9452480.

Ding et al (2007) Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival. J.Biol.Chem. 282 4702. PMID: 17135238.