1130

Material Data Sheet

LY 294002 hydrochloride

Price: $129.00
Catalog #: 1130

LY 294002 hydrochloride

Price: 
$119 $505
Quantity: 
5 mg25 mg

Product Information

MW: 
343.81
Purity: 
>99%
Activity: 

 

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC50 values are 0.31, 0.73, 1.06 and 6.60μM for PI 3-Kβ, PI 3-Kα, PI 3-Kδ and PI 3-Kγ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivoInhibits autophagic sequestration in rat hepatocytes. Negative control LY 303511 (Cat. No. 2418) also available.

Storage: 
Store at RT

Literature

References: 

 

Vlahos et al (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002). J.Biol.Chem. 269 5241. PMID: 8106507.

Blommaart et al (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 243 240. PMID: 9030745.

Chasserot-Golaz et al (1998) Possible involvement of phosphatidyl-3-kinase in regulated exocytosis: studies in chromaffin cells with inhibitor LY 294002. J.Neurochem. 70 2347. PMID: 9603199.

Ferrandi et al (2007) Phosphoinositide 3-kinase γ inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J.Pharmacol.Exp.Ther. 322 923. PMID: 17526805.