1097

Material Data Sheet

Taxol

Price: $125.00
Catalog #: 1097

Taxol

Price: 
$119 $439
Quantity: 
10 mg 50 mg
Data Sheet: 

Product Information

MW: 
853.92
Purity: 
>99%
Solubility: 
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Activity: 

Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis.

Storage: 
Store at +4°C

Literature

References: 

Merck Index 12 7117.

McGuire et al (1989) Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann.Intern.Med. 111 273. PMID: 2569287.

Rowinsky et al (1990) Taxol: a novel investigational antimicrotubule agent. J.Natl.Cancer Inst. 82 1247. PMID:1973737.

Rao et al (1999) Characterization of the taxol binding site on the microtubule. J.Biol.Chem. 274 37990. PMID:10608867.

Park et al (2004) Taxol induces caspase-10-dependent apoptosis. J.Biol.Chem. 279 51057. PMID: 15452117.