Product References

Boston Biochem's products have been used successfully in hundreds of UPP-related publications. We have listed our most recent references below to provide our customers with an exceptional resource for product use information. The references are organized to mirror our product divisions for easy location. Products referenced in each article are listed below in red. Please inquire to request archives as we have curated references back to 2003.

Proteasome

Hata T., et al. (2005) "Role of p21waf1/cip1 in effects of oxaliplatin in colorectal cancer cells." Mol. Canc. Ther. 4(10): 1585-1594.

PubMed ID: 16227409 | Product(s) Referenced: clasto-lactacystin [beta]-lactone (Lactacystin)

Kaneko-Oshikawa C., et al. (2005) "Mammalian E4 Is Required for Cardiac Development and Maintenance of the Nervous System." Mol. Cell. Biol. 25(24): 10953-10964.

PubMed ID: 16314518 | Product(s) Referenced: UFD substrate

Kus B., et al. (2005) "A High Throughput Screen to Identify Substrates for the Ubiquitin Ligase Rsp5." J. Biol. Chem. 280(33): 29470-29478.

PubMed ID: 15955809 | Product(s) Referenced: MG-132

Lotz C., et al. (2005) "Targeting Positive Regulatory Domain I-Binding Factor 1 and X Box-Binding Protein 1 Transcription Factors by Multiple Myeloma-Reactive CTL." J. Immunol. 175(2): 1301-1309.

PubMed ID: 16002735 | Product(s) Referenced: lactacystin

Marteijn J. A. F., et al. (2005) "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells." Blood 106(13): 4114-4123.

PubMed ID: 16118314 | Product(s) Referenced: proteasome substrate Suc-Leu-Leu-Val-Tyr-AMC

Maynard M. A., et al. (2005) "Human HIF-3[alpha] 4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma." FASEB J 19(11): 1396-1406.

PubMed ID: 16126907 | Product(s) Referenced: MG-132

Miyase S., et al. (2005) "Differential Regulation of Rad18 through Rad6-dependent mono- and poly-ubiquitination." J. Biol. Chem. 280(1): 515-524.

PubMed ID: 15509568 | Product(s) Referenced: 26 S proteins

Bartee E., et al. (2004) "Downregulation of Major Histocompatibility Complex Class I by Human Ubiquitin Ligases Related to Viral Immune Evasion Proteins." J. Virol. 78(3): 1109-1120.

PubMed ID: 14722266 | Product(s) Referenced: lactacystin

Bartee E., et al. (2004) "Downregulation of Major Histocompatibility Complex Class I by Human Ubiquitin Ligases Related to Viral Immune Evasion Proteins." J. Virol. 78(3): 1109-1120.

PubMed ID: 14722266 | Product(s) Referenced: lactacystin

Gottifredi V., et al. (2004) "Decreased p21 Levels Are Required for Efficient Restart of DNA Synthesis after S Phase Block." J. Biol. Chem. 279(7): 5802-5810.

PubMed ID: 14597617 | Product(s) Referenced: beta-lactone

Guo W., et al. (2004) "Differential Regulation of Components of the Ubiquitin-Proteasome Pathway during Lens Cell Differentiation." Invest. Ophthalmol. Vis. Sci. 45(4): 1194-1201.

PubMed ID: 15037588 | Product(s) Referenced: clasto-lactacystin [beta]-lactone

Hatao, F., et al. (2004) "Prolonged Toll-like receptor stimulation leads to down-regulation of IRAK-4 protein." J. Leukoc. Biol. 76(4): 904-908.

PubMed ID: http://www.jleukbio.org/content/76/4/904.long | Product(s) Referenced: Lactacystin

Mehle A., et al. (2004) "Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway." J. Biol. Chem. 279(9): 7792-7798.

PubMed ID: 14672928 | Product(s) Referenced: clasto-lactacystin [beta]-lactone

Nishikawa H., et al. (2004) "Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase." J. Biol. Chem. 279(6): 3916-3924.

PubMed ID: Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase. | Product(s) Referenced: 26 S proteasome

Sato K., et al. (2004) "Degradation of Fodrin by m-Calpain in Fibroblasts Adhering to Fibrillar Collagen I Gel." J. Biochem. (Tokyo) 136(6): 777-785.

PubMed ID: 15671488 | Product(s) Referenced: lactacystin

Zhang D. D., et al. (2004) "Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex." Mol. Cell. Biol. 24(24): 10941-10953.

PubMed ID: 15572695 | Product(s) Referenced: MG132

Coulombe, P., et al. (2003) “Rapid turnover of extracellular signal-regulated Kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation.” Mol. Cell. Biol. 23: 4542- .

PubMed ID: 12808096 | Product(s) Referenced: lactacystin

Doss-Pepe, E.W., et al. (2003). "Ataxin-3 interactions with Rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis." Mol. Cell. Biol 23(18): 6469-6483.

PubMed ID: 12944474 | Product(s) Referenced: Suc-LLVY-AMC

Jones, J.M., et al. (2003) "Autoubiquitylation of the V(D)J recombinase protein RAG1." PNAS 100(26): 15446-15451.

PubMed ID: 14671314 | Product(s) Referenced: clasto-lactacystin-[beta]-lactone

Okamura, T., et al. (2003) "Abnormally high expression of proteasome activator-γ in thyroid neoplasm." Clin. Endocrin. Metab. 88(3): 31374031383.

PubMed ID: 12629132 | Product(s) Referenced: clasto-lactacystin [beta]-lactone (I-100)

Parcellier, A., et al. (2003). "HSP27 is a ubiquitin-binding protein involved in I-κB[alpha] proteasomal degradation." Mol. Cell. Biol. 23(11):5790-5802 .

PubMed ID: 12897149 | Product(s) Referenced: 26S proteasome

Pham, L.V., et al. (2003). "Inhibition of constitutive NF-κB activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis." J. Immunol. 171:88-95.

PubMed ID: 12816986 | Product(s) Referenced: 20S proteasome

Shim, M., et al. (2003). "Lithium stabilizes the CCAAT/Enhancer-binding protein [alpha] (C/EBP[alpha]) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibitor of proteasomal activity." Genes Cells 11(7): 731-744.

PubMed ID: 12668682 | Product(s) Referenced: MG-132

Zhang D. D., et al. (2003) "Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress." Mol. Cell. Biol. 23(22): 8137-8151.

PubMed ID: 14585973 | Product(s) Referenced: MG132

Ohh, M., et al. (2002). "An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.” EMBO Reports 3(2): 177-182.

PubMed ID: 11818338 | Product(s) Referenced: ubiquitin aldehyde

Substrate Proteins

PubMed ID: 24100029 | Product(s) Referenced: mono-Ub
PubMed ID: 23287719 | Product(s) Referenced: Ub-7-amido-4-methylcoumarin (Ub-AMC)
PubMed ID: 23318177 | Product(s) Referenced: Suc-LLVY-AMC
PubMed ID: 23318177 | Product(s) Referenced: Suc-LLVY-AMC
PubMed ID: 23437325 | Product(s) Referenced: Ac-Arg-Leu-Arg-AMC
PubMed ID: 23437325 | Product(s) Referenced: Ac-Nle-Pro-Nle-Asp-AMC
PubMed ID: 23437325 | Product(s) Referenced: Suc-Leu-Leu-Val-Tyr-AMC
PubMed ID: 23459205 | Product(s) Referenced: His-s5a
PubMed ID: 23463011 | Product(s) Referenced: Ub-AFC
PubMed ID: 23375434 | Product(s) Referenced: ubiquitin-AMC
PubMed ID: 23401522 | Product(s) Referenced: Ub-AMC
PubMed ID: 23861750 | Product(s) Referenced: biotinylated-S5a

Rodriguez, K.A. et al. (2012) "Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat." PLoS ONE 7(5): e35890.

PubMed ID: 22567116 | Product(s) Referenced: butoxycarbonyl-LeuArgArg-AMC (Boc-LRR-AMC)

Rodriguez, K.A. et al. (2012) "Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat." PLoS ONE 7(5): e35890.

PubMed ID: 22567116 | Product(s) Referenced: carbobenzoxy-LeuLeuGlu-AMC (Z-LLE-AMC)

Rodriguez, K.A. et al. (2012) "Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat." PLoS ONE 7(5): e35890.

PubMed ID: 22567116 | Product(s) Referenced: succinyl-LeuLeuValTyr-7-amido-4-methylc​oumarin(Suc-LLVY-AMC)

Chou, Y.-W. et al. (2012) "Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease." Arch. Biochem. Biophys. 520(2): 74–80.

PubMed ID: 22391227 | Product(s) Referenced: ubiquitin-AFC

Reverdy, C. et al. (2012) "Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme." Chem. Biol. 19(4): 467–477.

PubMed ID: 22520753 | Product(s) Referenced: ubiquitin-AMC (ubiquitin-7-amido-4-methylcoumarin), SENP1, U-550

Blackburn C, Barrett C, Blank JL, et al. "Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome." Med. Chem. Commun. 2012 May 30;3(6):710–719. 

PubMed ID: 10.1039/C2MD20060K | Product(s) Referenced: purified human erythrocyte and peripheral blood monocyte 20S proteasomes, recombinant proteasomal activator PA28alpha, Z-LLE-AMC

Chung, D.-W.D. et al. (2012) "Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway." PLoS ONE 7(8): e43477.

PubMed ID: 22912882 | Product(s) Referenced: re-energizing buffer, human recombinant UBE1 E1, Suc-LLVY-AMC, human recombinant UBC E2, biotin conjugated ubiquitin, ubiquitin,

Guglielmotto, M. et al. (2012) "Aβ 1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation." Aging cell.

PubMed ID: 22726800 | Product(s) Referenced: ubiquitin-7-amino-4-methylcoumarin (ubiquitin-AMC)

Hochrainer, K. et al. (2012) "Reperfusion rather than ischemia drives the formation of ubiquitin aggregates after middle cerebral artery occlusion." Stroke 43(8): 2229–2235.

PubMed ID: 22700531 | Product(s) Referenced: synthetic peptide Succinyl-Leu-Leu-Val-Tyr-7- Amino-4-methylcoumarin

Kanga, S. et al. (2012) "A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit." PLoS ONE 7(6): e38071.

PubMed ID: 22723847 | Product(s) Referenced: Ubiquitin-AMC

Carvalho, A.N. et al. (2012) "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice." Mol. Neurobiol.

PubMed ID: 23129554 | Product(s) Referenced: Z-leucine-leucine-glutamic acid-7-amido-4-methylcoumarin (Z-LLE-AMC), Boc-leucine-arginine-arginine-7-amido-4-methylcoumarin (Boc-LRR-AMC), succcinyl-leucine-leucine-valine-tyro-sine-7-amido-4-methylcoumarin (Suc-LLVY-AMC), isopeptidase inhibitor (Ubiquitin aldehyde [Ubal]), MG132,

Henle, A.M. et al. (2012) "Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T Cells." J. Immunol.

PubMed ID: 23180824 | Product(s) Referenced: Suc-LLVY-AMC, synthetic lactacystin, reaction buffer (25 mM HEPES, 0.5 mM EDTA, pH 7.6), immunoproteasome, PA28 activator alpha subunit, purified human 20S proteasome

Lansdell, T.A. et al. (2012) "Non-competitive modulation of the proteasome by imidazoline scaffolds overcome bortezomib resistant and delay MM tumor growth in vivo." ACS Chem. Biol.

PubMed ID: 23198928 | Product(s) Referenced: purified proteasome particles, Suc-LLVY-AMC, Z-ARR-AMC, Z-LLE-AMC