Product References

Boston Biochem's products have been used successfully in hundreds of UPP-related publications. We have listed our most recent references below to provide our customers with an exceptional resource for product use information. The references are organized to mirror our product divisions for easy location. Products referenced in each article are listed below in red. Please inquire to request archives as we have curated references back to 2003.

E2 Conjugating

Koh, M.Y., et al. (2008) "Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1, Leading to Its Oxygen-Independent Degradation." Mol. Cell. Biol. 28 (23):7081-7095.

PubMed ID: 18838541 | Product(s) Referenced: human recombinant E2

Koutelou, E., et al. (2008) "Neuralized-like 1 (Neurl1) Targeted to the Plasma Membrane by N-Myristoylation Regulates the Notch Ligand Jagged1." J. Biol. Chem. 283: 3846-53.

PubMed ID: 18077452 | Product(s) Referenced: GST-tagged human UbcH2

Lagarou, A., et al. (2008) "KDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing." Genes & Dev. 22(20): 2799-2810.

PubMed ID: 18923078 | Product(s) Referenced: ubiquitin-conjugating enzyme UbcH5c

Lui, Q.Y., et al. (2008). "A novel brain-enriched E3 ubiquitin ligase RNF182 is up-regulated in the brains of Alzheimer’s patients and targets ATP6VOC for degradation." Molec. Degen. 3:4.

PubMed ID: 18298843 | Product(s) Referenced: Ubc5a

Maguire M., et al. (2008) "MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination." Canc. Res. 68: 3232-3242.

PubMed ID: 18451149 | Product(s) Referenced: UbcH5B

Malakhova O.A. and Zhang D-E. (2008) "ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response." J. Biol. Chem. 283: 8783-8787.

PubMed ID: 18287095 | Product(s) Referenced: Ub-conjugating enzyme UbcH6

Menon S., et al. (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.” BMC Biochem. 9:1.

PubMed ID: 18173839 | Product(s) Referenced: GST-UbcH5b

Ohtsubo M., et al. (2008) "Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity." PNAS 105(30): 10396-10401.

PubMed ID: 18650381 | Product(s) Referenced: ubiquitin-conjugating enzyme UbcH5c

Pebernard, S., et al. (2008) "Nse1 RING-like Domain Supports Functions of the Smc5-Smc6 Holo-complex in Genome Stability." Mol. Biol. Cell 19(10): 4099-4109.

PubMed ID: 18667531 | Product(s) Referenced: 6xHis-UbcH10, 6xHis-UbcH3, UbcH13/Uev1a, UbcH2, UbcH5a

Pierre S., et al. (2008) "Toponomics analysis of functional interactions of the ubiquitin ligase PAM during spinal nociceptive processing." Mol. Cell. Proteomics. 7(12)2475-2485.

PubMed ID: 18753128 | Product(s) Referenced: E2 proteins

Sehat B, et al. (2008). "Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis." Canc. Res. 68: 5669-5677.

PubMed ID: 18632619 | Product(s) Referenced: E2 (UbcH5B), mutated ubiquitin

Sekine K., et al. (2008). "Small Molecules Destabilize cIAP1 by Activating Auto-ubiquitylation." J. Biol. Chem. 283(14): 8961-8968.

PubMed ID: 18230607 | Product(s) Referenced: human UbcH5a

Tatematsu, K., et al. (2008) "Identification of Ubiquitin Ligase Activity of RBCK1 and Its Inhibition by Splice Variant RBCK2 and Protein Kinase C[beta]." J. Biol. Chem. 283: 11575-85.

PubMed ID: 18303026 | Product(s) Referenced: UbcH7

Umebayashi K., et al. (2008) "Ubc4/5 and c-Cbl Continue to Ubiquitinate EGF Receptor after Internalization to Facilitate Polyubiquitination and Degradation." Mol. Biol. Cell. 19(8): 3454-3462.

PubMed ID: 18508924 | Product(s) Referenced: GST-UbcH5A, UbcH5C, UbcH7

Varfolomeev E., et al. (2008) "c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor [alpha](TNF[alpha])-induced NF-κB Activation." J. Biol. Chem. 283(36): 24295-24299.

PubMed ID: 18621737 | Product(s) Referenced: UbcH13 (always used in complex with Uev1), UbcH5a

Lu, K., et al. (2008) "Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1." Nature cell biology 10(8): 994–1002.

PubMed ID: 18641638 | Product(s) Referenced: UbcH5c

Winter, M., et al. (2008) "Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR." Nature cell biology 10(7): 812–824.

PubMed ID: 18536714 | Product(s) Referenced: UbcH5b

Zhang, Z. and Zhang, R. (2008) "Proteasome activator PA28[gamma] regulates p53 by enhancing its MDM2-mediated degradation.” The EMBO journal 27(6): 852–864.

PubMed ID: 18309296 | Product(s) Referenced: UbcH5b

Catic A., et al. (2007) "Screen for ISG15-cross-reactive Deubiquitinases." PLoS ONE 2(7): E769.

PubMed ID: 17653289 | Product(s) Referenced: UbcH8

Hattori, T., et al. (2007) "Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27kip1." Can. Res. 67: 10789-10795.

PubMed ID: 18006823 | Product(s) Referenced: UbcH5b

Braun, M. A., et al. (2007). "Identification of Rkr1, a Nuclear RING Domain Protein with Functional Connections to Chromatin Modification in Saccharomyces cerevisiae." Mol. Cell. Biol. 27(8): 2800-2811.

PubMed ID: 17283062 | Product(s) Referenced: ubiquitin-conjugating enzyme (human recombinant UbcH5a)

Dul, B. E. and N. C. Walworth (2007). "The Plant Homeodomain Fingers of Fission Yeast Msc1 Exhibit E3 Ubiquitin Ligase Activity." J. Biol. Chem. 282(25): 18397-18406.

PubMed ID: 17456468 | Product(s) Referenced: human E2

Hong, K. U., et al. (2007). "Functional Importance of the Anaphase-Promoting Complex-Cdh1-Mediated Degradation of TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis." Mol. Cell. Biol. 27(10): 3667-3681.

PubMed ID: 17339342 | Product(s) Referenced: His6-UbcH10 (E2)

Jang, I.-C., et al. (2007). "Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling." Genes & Dev. 21(16): 2100-2111.

Product(s) Referenced: human E2 UbcH5b

Kamynina, E., et al. (2007). "Regulation of Proto-Oncogenic Dbl by Chaperone-Controlled, Ubiquitin-Mediated Degradation.” Mol. Cell. Biol. 27(5): 1809-1822.

PubMed ID: 17178836 | Product(s) Referenced: E2