Product References - Ubiquitin

Tsai, N.-P. et al. (2012) "Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95." Cell 151(7): 1581–1594.

Kostaras, E. et al. (2012) "SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking." Oncogene.

McIntyre, J. et al. (2012) "Ubiquitin mediates the physical and functional interaction between human DNA polymerases η and ι." Nucleic Acids Res.

Guo, Z. et al. (2012) "Sequential Posttranslational Modifications Program FEN1 Degradation during Cell-Cycle Progression." Molecular cell.

Choi, J.D. et al. (2012) "FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination." Oncogene.

Frisan, T. et al. (2012) "Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth." FASEB J.

Chung, D.-W.D. et al. (2012) "Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway." PLoS ONE 7(8): e43477.

Hu, X. et al. (2012) "Rap80 Protein Recruitment to DNA Double-strand Breaks Requires Binding to Both Small Ubiquitin-like Modifier (SUMO) and Ubiquitin Conjugates." J. Biol. Chem. 287(30): 25510–25519.

Zhuang, M. et al. (2012) "Substrates of IAP Ubiquitin Ligases Identified with a Designed Orthogonal E3 Ligase, the NEDDylator." Mol. Cell.

Zang, Y. et al. (2012) "Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage." Rice 5(1): 24.

Sikora, K.M. et al. (2012)"Expression of caytaxin protein in cayman ataxia mouse models correlates with phenotype severity." PLoS ONE 7(11): e50570.

Shibata, Y. et al. (2012) "p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO." Nat Commun 3: 1061.

Samara, N.L. et al. (2012) "A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity." Structure (London, England: 1993).

Nechama, M. et al. (2012) "An Unusual Two Step Control of CPEB Destruction by Pin1." Mol. Cell. Biol.

Mosbech, A. et al. (2012) "DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks." Nat. Struct. Mol. Biol. 19(11):1084-92.

Medina, B. et al. (2012) "The Ubiquitin Associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is Essential for the Recognition of Ubiquitin Proteasome System Substrates Both in vitro and in vivo." J. Biol. Chem.

Jung, Y.-S. et al. (2012) "Pirh2 E3 Ubiquitin Ligase Modulates Keratinocyte Differentiation through p63." J. Invest. Dermatol.

Ling, Q. et al. (2012) "Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system." Science 338(6107): 655–659.

Mattiroli, F. et al. (2012) "RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling." Cell 150(6): 1182–1195.

Hou, X. et al. (2012) "Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis." BMC Genomics 13: 495.

Fan, C.-D. et al. (2012) "Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the IGF-1 response." J. Biol. Chem.

Daniels, C.R. et al. (2012) "Exogenous Ubiquitin Modulates Chronic β-Adrenergic Receptor-Stimulated Myocardial Remodeling: Role in Akt Activity and Matrix Metalloproteinase Expression." Am. J. Physiol. Heart Circ. Physiol.

Huett, A. et al. (2012) "The LRR and RING Domain Protein LRSAM1 Is an E3 Ligase Crucial for Ubiquitin-Dependent Autophagy of Intracellular Salmonella Typhimurium." Cell Host Microbe 12(6): 778–790.

Bae, S. et al. (2012) "Akt is negatively regulated by the MULAN E3 ligase." Cell Res. 22(5): 873–885.

Gastaldello, S. et al. (2012) "Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1." Journal of molecular cell biology. 2012 Apr 3;

Lavorgna, A. and Harhaj, E.W. (2012) "An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation." J. Virol. 86(6): 3357–3369.

Markin, C.J. and Spyracopoulos, L. (2012) "Increased precision for analysis of protein-ligand dissociation constants determined from chemical shift titrations." Journal of biomolecular NMR. 2012 Apr 26;

Poulsen, M. et al. (2012) "Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks." J. Cell Biol. 197(2): 189–199.

Sambuughin, N. et al. (2012) "KBTBD13 interacts with Cullin 3 to form a functional ubiquitin ligase." Biochemical and biophysical research communications. 2012 Apr 20;

Vanni, E. et al. (2012) "Functional characterization of residues required for the herpes simplex virus type-1 E3 ubiquitin ligase ICP0 to interact with the cellular E2 ubiquitin-conjugating enzyme UBE2D1 (UbcH5a)." Journal of virology. 2012 Mar 21;

Kensche, T. et al. (2012) "Analysis of Nuclear Factor-κB (NF-κB) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-κB." J. Biol. Chem. 287(28): 23626–23634.

Sheng, Y. et al. (2012) "A human ubiquitin conjugating enzyme (E2) - HECT E3 ligase structure-function screen." Molecular & cellular proteomics: MCP. 2012 Apr 10;

Luo, K. et al. (2012) "Sumoylation of MDC1 is important for proper DNA damage response." The EMBO journal.  2012 May 25;

Chen, J. et al. (2012) "The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling." Genes Dev. 26(8): 803–815.

Schneider, S. et al. (2012) "Development of a homogeneous AlphaLISA ubiquitination assay using ubiquitin binding matrices as universal components for the detection of ubiquitinated proteins." Biochimica et biophysica acta. 2012 Apr 5;

Guo, H. et al. (2012) "E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity." Cell Reports 1: 472–482.

Shi, T. et al. (2012) "Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen." BMC chemical biology 12(1): 4.

Urbé, S. et al. (2012) "Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions." Mol. Biol. Cell 23(6): 1095–1103.

Xu, C. et al. (2012) "Degradation of MONOCULM 1 by APC/C(TAD1) regulates rice tillering." Nat Commun 3: 750.

Shabbeer, S. et al. (2012) "BRCA1 targets G2/M cell cycle proteins for ubiquitination and proteasomal degradation." Oncogene.

Cao, X., et al. (2011) “WW Domain-containing E3 Ubiquitin Protein Ligase 1 (WWP1) Delays Cellular Senescence by Promoting p27 Kip1 Degradation in Human Diploid Fibroblasts.” J. Biol. Chem. 286: 33447 - 33456.

Chen, B.B., et al (2011) “Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis.” Molecular and Cellular Biology: doi:10.1128/MCB.00723-10.” .

Cosper, P. and Leinwand, L. (2011) “Cancer Causes Cardiac Atrophy and Autophagy in a Sexually Dimorphic Manner.” Cancer Research, 71: 1710.

Cui, Y., et al. (2011) "SCFFBXL15 regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.” The EMBO Journal 30(13): 2675–2689.

Felle, M., et al. (2011). “The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1.” Nucleic Acids Res. 10.1093/nar/gkr528.

Gao, Y.F., et al. (2011). "Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability.” Nature Cell Biology 13(8): 924–933.

Hou, F., et al. (2011) "MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.” Cell 146(3): 448–461.

Huang, Z., et al. (2011) “Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells.” Nature Cell Biology, 13: 142-152.

James, T., et al. (2011) “Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease.” PNAS, 108: 2222-2227.

Kim, J., et al (2011) “Role of TRIM5[alpha] RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency Virus.” J. Virol. 85: 8116 - 8132.

Kuhlbrodt, K., et al. (2011) "The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.” Nature cell biology 13(3): 273–281.

Li, C., et al. (2011) "Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.” Oncogene 30(42): 4350–4364.

Lu, J., et al. (2011). “RNF170 Protein, an Endoplasmic Reticulum Membrane Ubiquitin Ligase, Mediates Inositol 1,4,5-Trisphosphate Receptor Ubiquitination and Degradation.” J. Biol. Chem. 286: 24426 - 24433.

Lui, T., et al. (2011). “The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/-catenin signaling.” Molecular and Cellular Biology: doi:10.1128/MCB.01094-10.

Mao, X., et al. (2011). “COMMD1 (Copper Metabolism MURR1 Domain-containing Protein 1) Regulates Cullin RING Ligases by Preventing CAND1 (Cullin-associated Nedd8-dissociated Protein 1) Binding.” J. Biol. Chem. 286: 32355 - 32365.

Nagel, C., et al. (2011) “Herpes Simplex Virus Immediate-Early Protein ICP0 Is Targeted by SIAH-1 for Proteasomal Degradation.” J. Virol. 85: 7644 - 7657.

Oberoi, T.K., et al. (2011) "IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.” The EMBO Journal 31(1): 14–28.

Saugar, I., et al. (2011) “The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA.” Nucleic Acids Res. 10.1093/nar/gkr738.

Solé, C., et al. (2011) "Control of Ubp3 ubiquitin protease activity by the Hog1 SAPK modulates transcription upon osmostress.” The EMBO Journal 30(16): 3274–3284.

Sun, X.X., et al. (2011) "Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.” The EMBO Journal 31(3): 576–592.

Sung, C.K., et al. (2011) “Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150Sal2.” The FASEB Journal fj.10-173674; published ahead of print January 12, 2011,doi:10.1096/fj.10-173674.

Tsz-Mei Lok, G., et al. (2011) “Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation.” Nucleic Acids Res. 10.1093/nar/gkr655.

Wakatsuki, S., et al. (2011) "ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.” Nature Cell Biology. 13(12):1415-23.

Wang, X., et al. (2011). “MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination.” J. Biol. Chem. 286: 23725 - 23734.

Wu, K., et al. (2011) “Mono-ubiquitination Drives Nuclear Export of the Human DCN1-like Protein hDCNL1.” J. Biol. Chem. 286: 34060 - 34070.

Yang, M., et al. (2011) “E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC.” J. Exp. Med. 208: 2099 - 2112.

Zhang, X., et al. (2011) "USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1.” The EMBO Journal 30(11): 2177–2189.

Zhao, R., et al. (2011) “Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.” JCI, 121: 851-865.

Wu, T., et al. (2010) “UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex.” PNAS 107: 1355 - 1360.

An, J.Y., et al. (2010) “UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.” PNAS 107: 1912 - 1917.

Archer, C. and Kodadek, T. (2010). “The hydrophobic patch of ubiquitin is required to protect transactivator–promoter complexes from destabilization by the proteasomal ATPases.” Nucleic Acids Res. 38: 789 - 796.

Artavanis-Tsakonas, K., et al. (2010). “Characterization and Structural Studies of the Plasmodium falciparum Ubiquitin and Nedd8 Hydrolase UCHL3.” J. Biol. Chem. 285: 6857 - 6866.

Clapp, K. M., et al. (2010) “C331A Mutant of Neuronal Nitric-oxide Synthase Is Labilized for Hsp70/CHIP (C Terminus of HSC70-interacting Protein)-dependent Ubiquitination.” J. Biol. Chem. 285: 33642-33651.

de Thonel, A., et al. (2010). “HSP27 controls GATA-1 protein level during erythroid cell differentiation.” Blood116: 85 - 96.

Dynek, J.N., et al. (2010) "c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.” The EMBO journal 29(24): 4198–4209.

Ensminger, A. and Isberg, R. (2010) “E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates.” Infect. Immun., 78: 3905 - 3919.

Ensminger, A. and Isberg, R. (2010) “E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates.” Infect. Immun., 78: 3905 - 3919.

Feng, L., et al. (2010). “The Lys63-specific Deubiquitinating Enzyme BRCC36 Is Regulated by Two Scaffold Proteins Localizing in Different Subcellular Compartments.” J. Biol. Chem. 285: 30982-30988.

Gastaldello, S., et al. (2010). "A deneddylase encoded by Epstein–Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.” Nature cell biology 12(4): 351–361.

Guo, Y., et al. (2010) “Blockade of the Ubiquitin Protease UBP43 Destabilizes Transcription Factor PML/RAR and Inhibits the Growth of Acute Promyelocytic Leukemia.” Cancer Res. 70: 9875-9885.

Hsia, M. M. and Callis, J. (2010) “BRIZ1 and BRIZ2 Proteins Form a Heteromeric E3 Ligase Complex Required for Seed Germination and Post-germination Growth in Arabidopsis thaliana.” J. Biol. Chem. 285: 37070-37081.

Kaneko, M., et al. (2010) “Loss of HRD1-Mediated Protein Degradation Causes Amyloid Precursor Protein Accumulation and Amyloid-[beta] Generation.” J. Neurosci., 3924 - 3932.

Kim, D. H., et al. (2010) “The CRL4Cdt2 Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA.” Mol. Cell. Biol. 30: 4120-4133.

Kops, G., et al. (2010) "APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome." J. Cell Sci. 123: 1623 - 1633.

Li, X.S., et al. (2010) "Mammalian SWI/SNF-A Subunit BAF250/ARID1 Is an E3 Ubiquitin Ligase That Targets Histone H2B." Mol. Cell. Biol. 30: 1673 - 1688.

Liu, J. and Ma, J. (2010) "Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos.” Nature cell biology 13(1): 22–29.

Marblestone, J. G., et al. (2010). “Novel Approach for Characterizing Ubiquitin E3 Ligase Function.” J. Biomol. Screen. 15: 1220-1228.

Mo, P., et al. (2010) “MDM2 Mediates Ubiquitination and Degradation of Activating Transcription Factor 3.” J. Biol. Chem. 285: 26908 - 26915.

Nie, J., et al. (2010) “Smad Ubiquitylation Regulatory Factor 1/2 (Smurf1/2) Promotes p53 Degradation by Stabilizing the E3 Ligase MDM2.” J. Biol. Chem. 285: 22818 - 22830.

Patterson-Fortin, J., et al. (2010) “Differential Regulation of JAMM Domain Deubiquitinating Enzyme Activity within the RAP80 Complex.” J. Biol. Chem. 285: 30971-30981.

Phan, V.T., et al. (2010) “The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans.” Mol. Cell. Biol. 30: 2264 - 2279.

Sadowski, M. et al. (2010) "Molecular Basis for Lysine Specificity in the Yeast Ubiquitin-Conjugating Enzyme Cdc34." Mol. Cell. Biol. 30: 2316 - 2329.

Singh, M., et al. (2010) "Extracellular ubiquitin inhibits [beta]-AR-stimulated apoptosis in cardiac myocytes: role of GSK-3[beta] and mitochondrial pathways." Cardiovasc Res. 86: 20 - 28.

Song, I. Y., et al. (2010) “Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway.” J. Biol. Chem. 285: 31525-31536.

Walters, M.S., et al. (2010) “The RING Finger Domain of Varicella-Zoster Virus ORF61p Has E3 Ubiquitin Ligase Activity That Is Essential for Efficient Autoubiquitination and Dispersion of Sp100-Containing Nuclear Bodies.” J. Virol. 84: 6861 - 6865.

Wang, H., et al. (2010). "Activating Transcription Factor 3 Activates p53 by Preventing E6-associated Protein from Binding to E6." J. Biol. Chem. 285: 13201 - 13210.

Wojdyla, J. A., et al. (2010) “Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates.” J. Virol. 84: 10063-10073.

Yang, Y., et al. (2010) “E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNF-induced JNK activation.” PNAS 107: 13444 - 13449.

Zeng, W., et al. (2010) "Reconstitution of the RIG-I Pathway Reveals a Pivotal Role of Unanchored Polyubiquitin Chains in Innate Immunity.” Cell 141(2): 315–330.

Bekker-Jensen, S., et al. (2009) "HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes.” Nature cell biology 12(1): 80–86.

Berthouze, M., et al. (2009) "The deubiquitinases USP33 and USP20 coordinate [beta]2 adrenergic receptor recycling and resensitization.” The EMBO journal 28(12): 1684–1696.

Burns, M., et al. (2009) "Parkin promotes intracellular A[beta]1–42 clearance." Hum. Mol. Genet. 18: 3206 - 3216.

Cohn, M.A., et al. (2009) "UAF1 Is a Subunit of Multiple Deubiquitinating Enzyme Complexes." J. Biol. Chem. 284 (8): 5343-5351.

Cooper, E.M., et al. (2009) "K63-specific deubuiquitination by two JAMM/MPN+ complexes:BRISC-associated Brcc-36 and proteasomal Poh1." EMBO J. 28(6) 621-631.

Cordier, F., et al. (2009) "The Zinc Finger of NEMO Is a Functional Ubiquitin-binding Domain.” J. Biol. Chem. 284(5): 2902-2907.

Garza, R.M., et al. (2009). "In Vitro Analysis of Hrd1p-mediated Retrotranslocation of its Multispanning Membrane Substrate 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase." J. Biol. Chem. 284: 14710-14722.

Kim, A.H., et al. (2009) "A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.” Cell 136(2): 322–336.

Kim, H.C. and J.M. Huibregtse (2009) "Poly-ubiquitination by HECT E3s and the Determinants of Chain Type Specificity." Mol. Cell. Biol. 29: 3307-3318.

Laplantine, E., et al. (2009) "NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.” The EMBO journal 28(19): 2885–2895.

Liu, Z., et al. (2009) "Human BRE1 Is an E3 Ubiquitin Ligase for Ebp1 Tumor Suppressor." Mol. Biol. Cell 20 (3): 757-768.

Maerki, S., et al. (2009). “The Cul3–KLHL21 E3 ubiquitin ligase targets Aurora B to midzone microtubules in anaphase and is required for cytokinesis.” J. Cell Biol. 187: 791 - 800.

Misaghi, S., et al. (2009) "Association of C-Terminal Ubiquitin Hydrolase BRCA1-Associated Protein 1 with Cell Cycle Regulator Host Cell Factor 1." Mol. Cell. Biol. 29: 2181-2192.

Nakao, R., et al. (2009) "Ubiquitin ligase Cbl-b is a negative regulator for IGF-1 signaling during muscle atrophy caused by unloading." Mol. Cell. Biol.: MCB.01347-08.

Persaud, A., et al. (2009) "Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.” Molecular systems biology 5(1).

Pierce, N.W., et al. (2009) "Detection of sequential polyubiquitylation on a millisecond timescale.” Nature 462(7273): 615–619.

Quezada, C.M., et al. (2009) "A family of Salmonella virulence factors functions as a distinct class of auto-regulated E3 ubiquitin ligases." PNAS 106 (12): 4864-4869.

Saeki, Y., et al. (2009) "Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome.” The EMBO journal 28(4): 359–371.

Shanks. J., et al. (2009) "Burkholderia mallei tssM Encodes a Putative Deubiquitinase That Is Secreted and Expressed inside Infected RAW 264.7 Murine Macrophages." Infect. Immun. 77 (4): 1636-1648.

Shenoy, S.K., et al. (2009) "b-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2." PNAS 106: 6650-6655.

Singh, R.K., et al. (2009) "Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis.” Nature cell biology 11(8): 925–933.

Stewart, G.S., et al. (2009) "The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage.” Cell 136(3): 420–434.

Uchiki T., et al. (2009) "The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition." J. Biol. Chem. 284: 12622-12632.

Wawrzynow, B., et al. (2009) "A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity." J. Biol. Chem. 284: 11517-11530.

Archer C.T., et al. (2008). "Physical and Functional Interactions of Monoubiquitylated Transactivators with the Proteasome." J. Biol. Chem. 283(31): 21789-21798.

Bazirgan O.A and Hampton R.Y. 2008. "Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo." J. Biol. Chem: 283(19):12797-810.

Choi, D.W., et al. (2008) "Ubiquitination and Degradation of Homeodomain-interacting Protein Kinase 2 by WD40 Repeat/SOCS Box Protein WSB-1." J. Biol. Chem. 283: 4682-4689.

Daulny, A., et al. (2008) "Modulation of RNA polymerase II subunit composition by ubiquitylation." PNAS 105(50): 19649-19654.

Heuzé, M.L., et al. (2008) "ASB2 targets filamins A and B to proteasomal degradation." Blood 112(13): 5130-5140.

Kawahara, K., et al. (2008) [alpha]-Synuclein Aggregates Interfere with Parkin Solubility and Distribution: ROLE "IN THE PATHOGENESIS OF PARKINSON DISEASE." J. Biol. Chem. 283: 6979-6987.

Koulich, E., et al. (2008) "Relative Structural and Functional Roles of Multiple Deubiquitylating Proteins Associated with Mammalian 26S Proteasome." Mol. Biol. Cell 19: 1072-82.

Li, Z., et al. (2008). "Cdc34p biquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein." J. Virol 82(14): 16911-6926.

Liu, L-J., et al. (2008) "COP1-Mediated Ubiquitination of CONSTANS Is Implicated in Cryptochrome Regulation of Flowering in Arabidopsis." Plant Cell. 20: 292-306.

Maguire M., et al. (2008). "MDM2 Regulates Dihydrofolate Reductase Activity through Monoubiquitination." Canc. Res. 68: 3232-3242.

Menon S., et al. (2008). "Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosome.” BMC Biochem. 9:1.

Mukai A., et al. (2008) “Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis.” J.Cell. Sci. 121: 1325-33.

Nicholson, B., et al. (2008). "Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities." Prot. Sci. 17: 1035-1043.

Oshima, S., et al. (2008) "ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development." Nature 457(7231): 906–909.

Prakash, S., et al. (2008) "Substrate selection by the proteasome during degradation of protein complexes." Nature chemical biology 5(1): 29–36.

Varfolomeev E., et al. (2008) "c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor [alpha](TNF[alpha])-induced NF-κB Activation." J. Biol. Chem. 283(36): 24295-24299.

Vega-Sanchez M.E., et al. (2008) "SPIN1, a K Homology Domain Protein Negatively Regulated and E3 Ubiquitin Ligase SPL11, Is Involved in Flowering Time Control in Rice." Plant Cell 20: 1456-1469.

Winborn, B.J., et al. (2008) "The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits K63-linkages in mixed linkage ubiquitin chains." J. Biol. Chem. 283(39):26436-26443.

Yamoah K., et al. (2008) "Molecular and Biochemical Characterization of the Skp2-Cks1 Binding Interface." PNAS 105(34):12230-12235.

Yasukawa, T., et al. (2008) "Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.” The EMBO Journal 27(24): 3256–3266.

Barriere, H., et al. (2007). "Plasticity of Poly-Ubiquitin Recognition as Lysosomal Targeting Signals by the Endosomal Sorting Machinery." Mol. Biol. Cell. 18(10) :3952-3965.

Braun, M. A., et al. (2007). "Identification of Rkr1, a Nuclear RING Domain Protein with Functional Connections to Chromatin Modification in Saccharomyces cerevisiae." Mol. Cell. Biol. 27(8): 2800-2811.

Chen, Z., Y. Wang, et al. (2007). "Proteolytic Processing and Deubiquitinating Activity of Papain-Like Proteases of Human Coronavirus NL63." J. Virol. 81(11): 6007-6018.

Ghaboosi, N. and R. J. Deshaies (2007). "A Conditional Yeast E1 Mutant Blocks the Ubiquitin-Proteasome Pathway and Reveals a Role for Ubiquitin Conjugates in Targeting Rad23 to the Proteasome." Mol. Biol. Cell 18(5): 1953-1963.

Joch, M., et al. (2007). "Parkin-mediated Mono-ubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels." Mol. Biol. Cell 18(8): 3105-3118.

Kerns, S. L., et al. (2007). "Geminin Prevents Re-replication during Xenopus Development." J. Biol. Chem. 282(8): 5514-5521.

Lamothe, B., et al. (2007). "Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation." J. Biol. Chem. 282(6):Determinant of I 4102-4112.

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