Product References - Substrate proteins

Boston Biochem's products have been used successfully in hundreds of UPP-related publications. We have listed our most recent references below to provide our customers with an exceptional resource for product use information. The references are organized to mirror our product divisions for easy location. Products referenced in each article are listed below in red. Please inquire to request archives as we have curated references back to 2003.

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23287719 | Ub-7-amido-4-methylcoumarin (Ub-AMC)
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23318177 | Suc-LLVY-AMC
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23318177 | Suc-LLVY-AMC
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23437325 | Ac-Arg-Leu-Arg-AMC
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23437325 | Ac-Nle-Pro-Nle-Asp-AMC
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23437325 | Suc-Leu-Leu-Val-Tyr-AMC
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23459205 | His-s5a
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23463011 | Ub-AFC
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23375434 | ubiquitin-AMC
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23401522 | Ub-AMC

Guglielmotto, M. et al. (2012) "Aβ 1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation." Aging cell.

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22726800 | ubiquitin-7-amino-4-methylcoumarin (ubiquitin-AMC)

Chung, D.-W.D. et al. (2012) "Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway." PLoS ONE 7(8): e43477.

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22912882 | re-energizing buffer, human recombinant UBE1 E1, Suc-LLVY-AMC, human recombinant UBC E2, biotin conjugated ubiquitin, ubiquitin,

Kanga, S. et al. (2012) "A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit." PLoS ONE 7(6): e38071.

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22723847 | Ubiquitin-AMC

Hochrainer, K. et al. (2012) "Reperfusion rather than ischemia drives the formation of ubiquitin aggregates after middle cerebral artery occlusion." Stroke 43(8): 2229–2235.

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22700531 | synthetic peptide Succinyl-Leu-Leu-Val-Tyr-7- Amino-4-methylcoumarin

Zhu, Y. et al. (2012) "Synthesis and inhibitory activities against colon cancer cell growth and proteasome of alkylresorcinols." J. Agric. Food Chem. 60(35): 8624–8631.

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22897570 | human 20S proteasome, proteasome activator PA28, Suc-Leu-Leu-Val-Tyr-AMC (Suc-LLVY-AMC)

Neilsen, P.M. et al. (2012) "New 26S Proteasome Inhibitors with High Selectivity for Chymotrypsin-Like Activity and p53-Dependent Cytotoxicity." ACS Chem. Biol.

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23190346 | purified rabbit20S proteasome, Suc-LLVY-AMC

Blackburn C, Barrett C, Blank JL, et al. "Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome." Med. Chem. Commun. 2012 May 30;3(6):710–719. 

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10.1039/C2MD20060K | purified human erythrocyte and peripheral blood monocyte 20S proteasomes, recombinant proteasomal activator PA28alpha, Z-LLE-AMC

Henle, A.M. et al. (2012) "Enzymatic Discovery of a HER-2/neu Epitope That Generates Cross-Reactive T Cells." J. Immunol.

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23180824 | Suc-LLVY-AMC, synthetic lactacystin, reaction buffer (25 mM HEPES, 0.5 mM EDTA, pH 7.6), immunoproteasome, PA28 activator alpha subunit, purified human 20S proteasome

Carvalho, A.N. et al. (2012) "Ubiquitin-Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice." Mol. Neurobiol.

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23129554 | Z-leucine-leucine-glutamic acid-7-amido-4-methylcoumarin (Z-LLE-AMC), Boc-leucine-arginine-arginine-7-amido-4-methylcoumarin (Boc-LRR-AMC), succcinyl-leucine-leucine-valine-tyro-sine-7-amido-4-methylcoumarin (Suc-LLVY-AMC), isopeptidase inhibitor (Ubiquitin aldehyde [Ubal]), MG132,

Lansdell, T.A. et al. (2012) "Non-competitive modulation of the proteasome by imidazoline scaffolds overcome bortezomib resistant and delay MM tumor growth in vivo." ACS Chem. Biol.

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23198928 | purified proteasome particles, Suc-LLVY-AMC, Z-ARR-AMC, Z-LLE-AMC

Rodriguez, K.A. et al. (2012) "Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat." PLoS ONE 7(5): e35890.

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22567116 | butoxycarbonyl-LeuArgArg-AMC (Boc-LRR-AMC)

Rodriguez, K.A. et al. (2012) "Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat." PLoS ONE 7(5): e35890.

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22567116 | carbobenzoxy-LeuLeuGlu-AMC (Z-LLE-AMC)

Rodriguez, K.A. et al. (2012) "Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat." PLoS ONE 7(5): e35890.

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22567116 | succinyl-LeuLeuValTyr-7-amido-4-methylc​oumarin(Suc-LLVY-AMC)

Chou, Y.-W. et al. (2012) "Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease." Arch. Biochem. Biophys. 520(2): 74–80.

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22391227 | ubiquitin-AFC

Reverdy, C. et al. (2012) "Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme." Chem. Biol. 19(4): 467–477.

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22520753 | ubiquitin-AMC (ubiquitin-7-amido-4-methylcoumarin), SENP1, U-550

Galisson, F., et al. (2011) “A Novel Proteomics Approach to Identify SUMOylated Proteins and Their Modification Sites in Human Cells.” Molecular and Cellular Proteomics, 10: M110.004796.

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21098080 | E2-25K

Wu, T., et al. (2010) “UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex.” PNAS 107: 1355 - 1360.

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20080579 | E2-25K

Kim, H.T., et al. (2009) "S5a promotes protein degradation by blocking synthesis of non-degradable forked ubiquitin chains." EMBO J. 28: 1867-1877.

Gho, A.M., et al. (2008). "Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins." BMC Biochem. 9:4.

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18234089 | E2-25K

Yamada, M., J. Ohnishi, et al. (2006). "NARF, an emo-like Kinase (NLK)-associated Ring Finger Protein Regulates the Ubiquitylation and Degradation of T Cell Factor/Lymphoid Enhancer Factor (TCF/LEF)." J. Biol. Chem. 281(30): 20749-20760.

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16714285 | E2-25K