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The enzymes
that
catalyze the removal of ubiquitin
from native conjugates, ubiquitin
C-terminal extension peptides,
ubiquitin precursor proteins, linear
poly-ubiquitin fusions or
disassembly of ubiquitin chains are
known as deconjugating enzymes (or
deubiquitinating enzymes, DUBs).
There are also enzymes that
specifically hydrolyze C-terminal
isopeptide bonds for ubiquitin-like
proteins: SUMO-specific proteases (SENPs),
NEDD8-specific proteases (NEDP1,
COP9 signalosome) and ISG15-specific
proteases (UBP43).
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