Linkage specific Poly-Ubiquitin (Ub) Chains are used to investigate mechanisms of binding and recognition by E1 or E2 enzymes, deubiquitinating enzymes, E3 ligases, or other proteins that contain ubiquitin-associated domains (UBAs) or ubiquitin interacting motifs (UIMs). Products are formed with wild-type ubiquitin and linkage-specific conjugating enzymes.
Lys48-linked Poly-Ub Chains are abundant in vivo and act as a universal signal for proteasomal degradation.
Lys63-linked Poly-Ub Chains have been implicated in several non-degradative processes such as receptor endocytosis and sorting, translation, DNA damage repair, the stress response and signaling in the NF-κB pathway.
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K48-Linked Chains |
K63-Linked Chains |
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- Ubiquitin1-7
- Ubiquitin2-7
- Ubiquitin3-7
- Di-Ubiquitin
- Tetra-Ubiquitin
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Cat.#: UC-240
Cat.#: UC-230
Cat.#: UC-220
Cat.#: UC-200
Cat.#: UC-210
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Cat.#: UC-340
Cat.#: UC-330
Cat.#: UC-320
Cat.#: UC-300
Cat.#: UC-310
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Custom Linked Chains
Ubiquitin Chains can be produced for specific research needs. Synthesis options include:
- Exact chain-length
- Use of tagged or mutant ubiquitin
- Fluorescein or biotin labeling
